Sky W. Reece, Ph.D.
Education
Ph.D. Physiology, Brody School of Medicine, East Carolina University
M.S. Biomedical Engineering, West China Medical Center, Sichuan University, China
B.E. Engineering, Xihua University, China
Teaching
I teach pharmacology and toxicology to medical, dental, nurse anesthesia, and graduate students. I serve as course director for graduate courses and for Advanced Pharmacology for Nurse Anesthetists. I also serve as a liaison between the School of Dental Medicine and the Department of Pharmacology and Toxicology, coordinating lectures in the dental curriculum.
My teaching extends beyond the lecture hall. I help develop case-based learning sessions for first-year medical students through the Contextual Learning Activity Workgroup and facilitate those sessions. I also facilitate problem-based learning in Foundations of Doctoring I and clinical simulation labs for first- and second-year medical students.
Research
My current scholarship focuses on health professions education, particularly how instructional approaches affect students’ mastery of foundational pharmacology. I study how different instructional approaches and learning formats support students’ understanding of pharmacokinetics and pharmacodynamics.
Previously, my research examined how environmental exposures, including air pollutants, allergens, and nanoparticles, affect immune responses in the lungs and contribute to lung disease.
Selected Publications
Christine E Psaltis Matthews, Lynn A Fussner, Michael Yaeger, Jim J Aloor, Sky W Reece, Brita J Kilburg-Basnyat, Sanjay Varikuti, Bin Luo, Morgan Inks, Selin Sergin, Cameron A Schmidt, P Darrell Neufer, Edward Ross Pennington, Kelsey H Fisher-Wellman, Saiful M Chowdhury, Michael B Fessler, Jenifer I Fenton, Ethan J Anderson, Saame Raza Shaikh, Kymberly M Gowdy. The prohibitin complex regulates macrophage fatty acid composition, plasma membrane packing, and lipid raft-mediated inflammatory signaling. Prostaglandins Leukot Essent Fatty Acids. 2023 Mar:190:102540.
Katelyn Dunigan-Russell, Michael J Yaeger, Myles X Hodge, Brita Kilburg-Basnyat, Sky W Reece, Anastasiya Birukova, Marissa A Guttenberg, Caymen Novak, Sangwoon Chung, Brandie Michelle Ehrmann, E Diane Wallace, Debra Tokarz, Nairrita Majumder, Li Xia, John W Christman, Jonathan Shannahan, Megan N Ballinger, Salik Hussain, Saame Raza Shaikh, Robert M Tighe, Kymberly M Gowdy. Scavenger receptor BI attenuates oxidized phospholipid-induced pulmonary inflammation. Toxicol Appl Pharmacol. 2023 Mar 1;462:116381.
Michael J Yaeger, Sky W Reece, Brita Kilburg-Basnyat, Miles X Hodge, Anandita Pal, Katelyn Dunigan-Russell, Bin Luo, Dorothy J You, James C Bonner, Espen E Spangenburg, Debra Tokarz, Johanna Hannan, Michael Armstrong, Jonathan Manke, Nichole Reisdorph, Robert M Tighe, S Raza Shaikh, Kymberly M Gowdy. Sex Differences in Pulmonary Eicosanoids and Specialized Pro-Resolving Mediators in Response to Ozone Exposure. Toxicol Sci. 2021 Aug 30;183(1):170-183.
Sky W Reece, Sanjay Varikuti, Brita Kilburg-Basnyat, Katelyn Dunigan-Russell, Myles X Hodge, Bin Luo, Jennifer H Madenspacher, Seddon Y Thomas, Debra A Tokarz, Robert M Tighe, Donald N Cook, Michael B Fessler, Kymberly M Gowdy. Scavenger Receptor BI Attenuates IL-17A-Dependent Neutrophilic Inflammation in Asthma. Am J Respir Cell Mol Biol. 2021 Jun;64(6):698-708.
Melissa Iñigo, Adam Amorese, Michael Tarpey, Nicholas Balestrieri, Keith Jones, Daniel Patteson, Kathryn Jackson, Maria Torres, Chien-Te Lin, Cody Smith, Tim Heden, Shawna McMillin, Luke Weyrauch, Erin Stanley, Cameron Schmidt, Brita B. Kilburg-Basnyat, Sky W Reece, Christine Psaltis, Leslie Leinwand, Katsu Funai, Joseph McClung, Kymberly Gowdy, Carol Witczak, Dawn Lowe, P. Darrell Neufer, Espen Spangenburg. Estrogen receptor-α in female skeletal muscle is not required for regulation of muscle insulin sensitivity and mitochondrial regulation. Mol Metab. 2020 Apr;34:1-15.
Dylan K. McDaniel, Veronica M. Ringel-Scaia, Sheryl Coutermarsh-Ott, McAlister Council-Troche, Jonathan W. Angle, Justin B. Perry, Grace Davis, Weinan Leng, Valerie Minarchick, Yi Yang, Bo Chen, Sky W Reece, David A Brown, Thomas Cecere, Jared Brown, Kymberly M Gowdy, Michael F Hochella Jr, Irving Coy Allen. Pulmonary Exposure to Magnéli Phase Titanium Suboxides Results in Significant Macrophage Abnormalities and Decreased Lung Function. Front Immunol. 2019 Nov; 10: 2714
Myles X. Hodge, Sky W. Reece, Jennifer H. Madenspacher, Kymberly M. Gowdy. In vivo assessment of alveolar macrophage efferocytosis following ozone exposure. J. Vis. Exp. 2019 Oct; (152)
Robert M. Tighe, Anastasiya Birukova, Michael J. Yeager, Sky W. Reece, Kymberly M. Gowdy. Euthanasia and Lavage Mediated Effects on Bronchoalveolar Measures of Lung Injury and Inflammation. Am J Respir Cell Mol Biol. 2018 Aug; 59(2)
Brita Kilburg-Basnyat, Sky W. Reece, Miranda J. Crouch, Bin Luo, Andria D. Boone, Michael Yaeger, Myles Hodge, Christine Psaltis, Johanna L. Hannan, Michael L. Armstrong, Nicole Reisedorph, Robert M. Tighe, S. Raza Shaikh, Kymberly M. Gowdy. Specialized pro-resolving lipid mediators regulate ozone-induced pulmonary and systemic inflammation. Toxicol Sci. 2018 Feb; 19
Stephan Lefcoski, Kimberly Kew, Shaun Reece, Justin Parks, Sky Reece, Lisandra E. de Castro Brás, and Jitka A. I. Virag. Anatomical-Molecular Distribution of EphrinA1 in Infarcted Mouse Heart Using MALDI Mass Spectrometry Imaging. J Am Soc Mass Spectrom. 2018 Mar; 29(3): 527-534
Xiaojia Wang (Sky W Reece), Jonathan H. Shannahan, Jared M. Brown. IL-33 modulates chronic airway resistance changes induced by multi-walled carbon nanotubes. Inhal Toxicol. 2014 Mar;26(4):240-9.
Xiaojia Wang (Sky W Reece), Ramakrishna Podila, Jonathan H. Shannahan, Apparao M. Rao, Jared M. Brown. Intravenously delivered graphene nanosheets and multi-walled carbon nanotubes induce site specific Th2 inflammatory responses via the IL-33/ST2 axis. Int. J. Nanomedicine 2013; 8: 1733-1748.
Xiaojia Wang (Sky W. Reece), Pranita Katwa, Pu Chun Ke, Ramakrishna Podila, Apparao Rao, Dianne M. Walters, Christopher J. Wingard, Jared M. Brown. Multi-walled carbon nanotube instillation impairs pulmonary function in C57BL/6 mice. Part Fibre Toxicol.2011 Aug 18; 8(1):24.
Xiaojia Wang (Sky W. Reece), Shaun Reece, Michael R. Van Scott, Jared M. Brown. A circadian clock in murine bone marrow-derived mast cells modulates IgE-dependent activation in vitro. Brain Behav Immun. 2011 Jan; 25(1):127-34.